abstract::Topotecan is potent anti-cancer drug approved for various malignancies but hematopoietic toxicities undermine its wider application and use of its most effective dose. This study aims to improve these limitations through inhalation-delivery. The pharmacokinetics, efficacy, and toxicity of 2-5 times lower inhalation do...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1912209
更新日期:2021-12-01 00:00:00
abstract::Many of the bioactive substances used in pharmaceutical industry are easily affected by temperature, light and oxygen, and are easily degraded during storage and processing, and exhibit poor adsorption properties during digestion, which limits their direct use. Microalgae are rich in oils which have antimicrobial prop...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章
doi:10.1080/21691401.2021.1906263
更新日期:2021-12-01 00:00:00
abstract::Upon infection of hepatocyte, Hepatitis B virus (HBV) genomic DNA in nucleocapsid is transported into the nucleus and converted into a covalently closed circular (ccc) DNA to serve as the template for transcription of viral RNAs. Viral DNA in the cytoplasmic progeny nucleocapsid is another resource to fuel cccDNA ampl...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1919034
更新日期:2021-12-01 00:00:00
abstract::The severe course of COVID-19 causes systemic chronic inflammation and thrombosis in a wide variety of organs and tissues. The nature of these inflammations remains a mystery, although they are known to occur against the background of a high level of cytokine production. The high level of cytokines provokes overproduc...
journal_title:Prionpub_type: 杂志文章
doi:10.1080/19336896.2021.1910468
更新日期:2021-12-01 00:00:00
abstract::The emergence and spread of carbapenemase-producing bacteria are serious threats to public health. We characterized two OXA-181-producing Escherichia coli isolates from pediatric patients with diarrhea from Ghana. blaOXA-181 was localized on the self-conjugative IncX3-containing plasmid in the E. coli ST410 isolate, b...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1920342
更新日期:2021-12-01 00:00:00
abstract:PURPOSE:The influence of prior failed kidney transplants on outcomes of peritoneal dialysis (PD) is unclear. Thus, we conducted a systematic review and meta-analysis to compare the outcomes of patients initiating PD after a failed kidney transplant with those initiating PD without a prior history of kidney transplantat...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1914659
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Capsule of alkaloids from the leaf of Alstonia scholaris (L.) R.Br. (Apocynaceae) (CALAS) is a new investigational botanical drug (No. 2011L01436) for bronchitis, post-infectious cough and asthma. OBJECTIVE:To observe the clinical safety and tolerability of CALAS. MATERIALS AND METHODS:Subjects were assigned ...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1893349
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate how modifications at the periphery of the porphyrin ring affect the anticancer activity of Mn porphyrins (MnPs)-based SOD mimics. METHODS:Six compounds: MnTE-2-PyP with a short ethyl chain on the pyridyl ring; MnTnHexOE-2-PyP and MnTnOct-2-PyP with linear 8-atom alkyl...
journal_title:Redox report : communications in free radical researchpub_type: 杂志文章
doi:10.1080/13510002.2021.1917214
更新日期:2021-12-01 00:00:00
abstract::In the porcine model discussed in this review, the acute subdural hematoma was induced by subdural injection of autologous blood over the left parietal cortex, which led to a transient elevation of the intracerebral pressure, measured by bilateral neuromonitoring. The hematoma-induced brain injury was associated with ...
journal_title:Neural regeneration researchpub_type: 杂志文章,评审
doi:10.4103/1673-5374.313018
更新日期:2021-12-01 00:00:00
abstract::11C-PK11195 is a positron emitter tracer used for Positron Emission Tomography (PET) imaging of innate immune cell activation in studies of neuroinflammatory diseases. For the image quantitative analysis, it is necessary to quantify the intact fraction of this tracer in the arterial plasma during imaging acquisition (...
journal_title:Neural regeneration researchpub_type: 杂志文章
doi:10.4103/1673-5374.313062
更新日期:2021-12-01 00:00:00
abstract::Barriers to access abortion services globally have led to the development of alternative methods to assist and support women who seek an abortion. One such method is the use of hotlines, currently utilised globally for abortion care. This review aimed to understand (1) how abortion hotlines facilitate access to aborti...
journal_title:Sexual and reproductive health matterspub_type: 杂志文章
doi:10.1080/26410397.2021.1907027
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Cryptotanshinone (CT), a lipophilic compound extracted from roots of Salvia miltiorrhiza Bunge (Lamiaceae) (Danshen), has multiple properties in diseases, such as pulmonary fibrosis, lung cancer, and osteoarthritis. Our previous findings suggest that CT plays a protective role in cerebral stroke. However, the m...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1914672
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Studies have shown that the use of statins could significantly improve lipid profiles; however, it remains controversial whether the use of statins could improve renal function in patients with chronic kidney disease (CKD). Therefore, we conducted a meta-analysis of randomized controlled trials (RCTs) to eva...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1915799
更新日期:2021-12-01 00:00:00
abstract::T7 peptide is considered as an antiangiogenic polypeptide. The presents study aimed to further detect the antiangiogenic mechanisms of T7 peptide and determine whether combining T7 peptide and meloxicam (COX-2/PGE2 specific inhibitor) could offer a better therapy to combat hepatocellular carcinoma (HCC). T7 peptide su...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1914776
更新日期:2021-12-01 00:00:00
abstract::Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is oncogenic in multiple cancers. Herein, the present study is aimed at delving into how XIST functions in retinoblastoma (RB) and investigating its underlying mechanism. In this study, XIST, miR-191-5p, BDNF mRNA, and BDNF expression levels in RB tiss...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1918991
更新日期:2021-12-01 00:00:00
abstract::A cytoskeletal protein keratin 19 (K19) is highly expressed in breast cancer but its effects on breast cancer cell mechanics are unclear. In MCF7 cells where K19 expression is ablated,we found that K19 is required to maintain rounded epithelial-like shape and tight cell-cell adhesion. A loss of K19 also lowered cell s...
journal_title:Cell adhesion & migrationpub_type: 杂志文章
doi:10.1080/19336918.2020.1868694
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:During the COVID-19 pandemic, hospital staff have experienced a variety of mental health challenges. European research on anxiety and stress among hospital workers during the pandemic is limited. This study aimed to describe the anxiety levels of Finnish hospital workers during the COVID-19 pandemic. METHOD...
journal_title:Annals of medicinepub_type: 杂志文章,多中心研究
doi:10.1080/07853890.2020.1862905
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVE:We investigated the impact of multimorbidity and polypharmacy on the management of atrial fibrillation (AF) patients in clinical practice and assessed factors associated with polypharmacy and oral anticoagulation (OAC) use in AF patients with multimorbidity and polypharmacy. METHODS:A 14-week prospective stu...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2020.1799241
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Patients with chronic kidney disease, especially those receiving hemodialysis (HD), are at risk of hyperkalemia (HK). This systematic review aimed to evaluate the prevalence of HK in patients with renal disease receiving HD and collate evidence on the effect of HK and differing HD patterns (i.e., long vs. sh...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2020.1871012
更新日期:2021-12-01 00:00:00
abstract:INTRODUCTION:Extracorporeal shock wave lithotripsy (ESWL) is a noninvasive modality to treat urolithiasis, with complications including tissue damage and hematoma of kidney parenchyma. Anti-glomerular basement membrane (GBM) disease is suggested to be a rare complication of ESWL since it was reported in several cases t...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2020.1869042
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Long-term dietary phosphorus excess influences disturbances in mineral metabolism, but it is unclear how rapidly the mineral metabolism responds to short-term dietary change in dialysis populations. METHODS:This was a post hoc analysis of a randomized crossover trial that evaluated the short-term effects of...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2020.1870138
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Progression of Benign Prostate hyperplasia (BPH) is vulnerable to oxidative stress (OS) and prostatic enlargement among the aging males through apoptosis deregulation. Our present study aimed to investigate the effect of neferine (NF) in the regulation of oxidative stress and apoptosis in human BPH-1 cells. ...
journal_title:Redox report : communications in free radical researchpub_type: 杂志文章
doi:10.1080/13510002.2021.1871814
更新日期:2021-12-01 00:00:00
abstract::The aim of the present study was to investigate the pharmacological mechanism of matrine in treatment of COVID-19 combined with liver injury. Potential targets related to matrine, COVID-19 and liver injury were identified from several databases. We constructed PPI network and screened the core targets according to the...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1879313
更新日期:2021-12-01 00:00:00
abstract::In the current study, new thienopyrimidine conjugates bearing 1,2,3-triazole core and different sugar moieties have been designed and synthesized by Cu(I)-catalysed click dipolar cycloaddition. The cytotoxic activity of the synthesised conjugates 2, 5, 7, and 13-18 was studied against HCT-116 and MCF-7 cell lines by t...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1871335
更新日期:2021-12-01 00:00:00
abstract::Colorectal cancer is one of the most common cancers in the United States and treatment options are limited for patients who develop liver metastases. Several chemotherapeutic regimens have been used for transvascular liver-directed therapy in the treatment of colorectal liver metastases without clear evidence of super...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2020.1869863
更新日期:2021-12-01 00:00:00
abstract::Venezuelan equine encephalitis virus (VEEV) is an encephalitic alphavirus that can cause debilitating, acute febrile illness and potentially result in encephalitis. Currently, there are no FDA-licensed vaccines or specific therapeutics for VEEV. Previous studies have demonstrated that VEEV infection results in increas...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2020.1870834
更新日期:2021-12-01 00:00:00
abstract::This study developed a novel method for the rapid detection of Escherichia coli (E. coli) O157:H7 on a microfluidic platform. First, the concentration of bacteria in a sample was determined with the adenosine triphosphate (ATP) method. Then, the specific detection of E. coli was achieved in a microfluidic chip by the ...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2020.1870805
更新日期:2021-12-01 00:00:00
abstract::Current studies indicated that immune-associated genes (IAGs) have important roles in the occurrence and development of bladder cancer (BC). The current work aims to identify the prognostic values of IAGs in BC and establish a prognostic signature based on IAGs. RNA sequencing data and protein expression data were use...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章
doi:10.1080/21691401.2020.1865994
更新日期:2021-12-01 00:00:00
abstract::Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19). Since its emergence, the COVID-19 pandemic has not only distressed medical services but also caused economic upheavals, marking urgent the need for effective therapeutics. The experience of combating SA...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1850710
更新日期:2021-12-01 00:00:00
abstract::Determination of thyroid-stimulating hormone (TSH) level in serum or plasma is defined as a sensitive method for the diagnosis of hyperthyroidism and hypothyroidism and also in many diseases thought to be related to TSH levels. In this study, a novel simple impedimetric immunosensor based on polyamidoamine dendrimer w...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章
doi:10.1080/21691401.2020.1867153
更新日期:2021-12-01 00:00:00
abstract:PURPOSE:The purpose of the study is to explore how professionals working with suicide prevention experience the influence of the national guidelines on mental healthcare, and to gather recommendations for which steps to take next. METHODS:This is a qualitative study with an explorative design. We interviewed 22 profes...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2020.1868737
更新日期:2021-12-01 00:00:00
abstract::The incidence of fungal infections has increased continuously in recent years. Caspofungin (CAS) is one of the first-line drugs for the treatment of systemic fungal infection. However, the emerging CAS-resistant clinical isolates and high economic cost for CAS administration hamper the wide application of this drug. T...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2020.1870079
更新日期:2021-12-01 00:00:00
abstract::Nanoparticles (NPs) have biological activities like antibacterial, antifungal, drug delivery, immunomodulation and antitumor activities. The aim of the current study was to investigate some of biomedical applications of silver NP synthesis using extracts from leaves of Eriobotrya japonica. Colour changes, UV-visible s...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章
doi:10.1080/21691401.2020.1867152
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVES:The remarkable effect of arsenic trioxide (ATO) was verified, but elevated gamma-glutamyltransferase (GGT), aminotransferases (ALT and AST) are generally observed in acute promyelocytic leukemia (APL) patients undergoing ATO treatment. However, utilization of hepatoprotective agents or discontinuation of ATO...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2020.1868782
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVES:A new regulatory subpopulation of innate lymphoid cells (ILCs), regulatory innate lymphoid cells (ILCregs), has been identified with both innate lymphoid cells and regulatory cells characteristics. The purpose of this study is to explore ILCregs and its associated miRNAs in patients with aplastic anemia (AA)...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2020.1866304
更新日期:2021-12-01 00:00:00
abstract::Enteroaggregative Escherichia coli (EAEC) is a common diarrhoeagenic human pathogen, isolated from patients in both developing and industrialized countries, that is becoming increasingly resistant to many frontline antibiotics. In this study, we screened 50 E. coli strains from children presenting with diarrhea at the...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2020.1859852
更新日期:2021-12-01 00:00:00
abstract::Transmission of severe acute respiratory coronavirus-2 (SARS-CoV-2) between livestock and humans is a potential public health concern. We demonstrate the susceptibility of rabbits to SARS-CoV-2, which excrete infectious virus from the nose and throat upon experimental inoculation. Therefore, investigations on the pres...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2020.1868951
更新日期:2021-12-01 00:00:00
abstract::Lipids are complex organic compounds made up of carbon, oxygen, and hydrogen. These play a diverse and intricate role in cellular processes like membrane trafficking, protein sorting, signal transduction, and bacterial infections. Both Gram-positive bacteria (Staphylococcus sp., Listeria monocytogenes, etc.) and Gram-...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2020.1869441
更新日期:2021-12-01 00:00:00
abstract::Rapid industrialization has provided comforts to mankind but has also impacted the environment harmfully. There has been severe increase in the pollution due to several industries, in particular due to dye industry, which generate huge quantities of wastewater containing hazardous chemicals. Although tremendous develo...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2020.1863034
更新日期:2021-12-01 00:00:00
abstract::One of the systems responsible for maintaining cellular redox homeostasis is the thioredoxin-dependent system. An equally important function of this system is the regulation of the expression of many proteins by the transcription factor NF-κB or the apoptosis regulating kinase (ASK-1). Since it has been shown that the...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1867121
更新日期:2021-12-01 00:00:00